About this game

San Francisco 49ers vs New Orleans Saints Final Score, Odds & Picks

NFL · Sunday, September 14, 2025, 1:01 PM ET · Caesars Superdome, New Orleans, LA · TV: Fox

Final: San Francisco 49ers 26, New Orleans Saints 21.

Records: San Francisco 49ers 2-0, New Orleans Saints 0-2.

49ers vs Saints scoring plays

  • Final: 49ers 26, Saints 21 · 4:08 PM ET · San Francisco 49ers beat New Orleans Saints 26-21.
  • Saints score: 49ers 26, Saints 21 (Q4 6:18) · 3:45 PM ET · (Shotgun) S.Rattler pass short middle to D.Vele for 3 yards, TOUCHDOWN. B.Grupe extra point is GOOD, Center-Z.Wood, Holder-K.Kroeger.
  • 49ers score: 49ers 26, Saints 14 (Q4 12:18) · 3:29 PM ET · (Shotgun) M.Jones pass deep middle to J.Jennings for 42 yards, TOUCHDOWN. E.Pineiro extra point is GOOD, Center-J.Weeks, Holder-T.Morstead.
  • 49ers score: 49ers 19, Saints 14 (Q3 3:20) · 3:11 PM ET · E.Pineiro 46 yard field goal is GOOD, Center-J.Weeks, Holder-T.Morstead.
  • Saints score: 49ers 16, Saints 14 (Q3 7:11) · 3:02 PM ET · (Shotgun) S.Rattler pass short right to R.Shaheed for 3 yards, TOUCHDOWN. B.Grupe extra point is GOOD, Center-Z.Wood, Holder-K.Kroeger.
  • 49ers score: 49ers 16, Saints 7 (Q2 0:07) · 2:30 PM ET · (Shotgun) M.Jones pass short right to C.McCaffrey for 7 yards, TOUCHDOWN. E.Pineiro extra point is GOOD, Center-J.Weeks, Holder-T.Morstead.
  • Saints score: 49ers 9, Saints 7 (Q2 1:14) · 2:17 PM ET · (Shotgun) S.Rattler pass deep left to J.Johnson for 18 yards, TOUCHDOWN.The Replay Official reviewed the pass completion ruling, and the play was Upheld. The ruling on the field stands. B.Grupe extra point is GOOD, Center-Z.Wood, Holder-K.Kroeger.
  • 49ers score: 49ers 9, Saints 0 (Q2 11:23) · 1:53 PM ET · E.Pineiro 44 yard field goal is GOOD, Center-J.Weeks, Holder-T.Morstead.
  • 49ers score: 49ers 6, Saints 0 (Q1 3:25) · 1:35 PM ET · M.Jones pass short left to L.Farrell for 11 yards, TOUCHDOWN. E.Pineiro extra point is No Good, Wide Right, Center-J.Weeks, Holder-T.Morstead.

San Francisco 49ers vs New Orleans Saints odds (DraftKings)

Spread: New Orleans Saints +5.5 (-345) · San Francisco 49ers -5.5 (+250)

Total: Over 47.5 (+230) · Under 47.5 (-315)

San Francisco 49ers vs New Orleans Saints picks

1 pick on Picksy: 49ers ML; 0 won, 1 lost.

Who picked this game

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49ers vs Saints: questions & answers

Who won 49ers vs Saints?

The San Francisco 49ers beat the New Orleans Saints 26-21 on Sunday, September 14, 2025.

Who was favored in 49ers vs Saints?

The San Francisco 49ers were favored at DraftKings: -5.5 on the spread.

What's the over/under for 49ers vs Saints?

The total was 47.5 points at DraftKings (over +230, under -315). The game finished with 47, under the total.

What are the picks for 49ers vs Saints?

1 pick on Picksy: 49ers ML; 0 won, 1 lost.