About this game

Detroit Lions vs Arizona Cardinals Final Score, Odds & Picks

NFL · Sunday, October 11, 2026, 4:25 PM ET · State Farm Stadium, Glendale, AZ · TV: Fox

Final: Detroit Lions 45, Arizona Cardinals 21.

Records: Detroit Lions 3-2, Arizona Cardinals 1-4.

Lions vs Cardinals scoring plays

  • Final: Lions 45, Cardinals 21 · 7:27 PM ET · Detroit Lions beat Arizona Cardinals 45-21.
  • Cardinals score: Lions 45, Cardinals 21 (Q4 2:11) · 7:18 PM ET · (Shotgun) J.Brissett pass short right to T.McBride for 9 yards, TOUCHDOWN. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
  • Lions score: Lions 45, Cardinals 14 (Q4 5:03) · 7:07 PM ET · J.Gibbs right end for 3 yards, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Lions score: Lions 38, Cardinals 14 (Q3 1:05) · 6:42 PM ET · J.Goff up the middle for 1 yard, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Cardinals score: Lions 31, Cardinals 14 (Q3 4:22) · 6:34 PM ET · J.Brissett pass short right to T.Quitoriano for 13 yards, TOUCHDOWN. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
  • Lions score: Lions 31, Cardinals 7 (Q3 9:42) · 6:22 PM ET · (Shotgun) J.Goff pass deep right to J.Williams for 39 yards, TOUCHDOWN. ARZ-W.Nolen was injured during the play. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Lions score: Lions 24, Cardinals 7 (Q2 0:53) · 5:55 PM ET · J.Bates 46 yard field goal is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Lions score: Lions 21, Cardinals 7 (Q2 4:50) · 5:40 PM ET · (Shotgun) J.Goff pass short left to J.Williams for 8 yards, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Lions score: Lions 14, Cardinals 7 (Q2 9:30) · 5:27 PM ET · J.Goff pass short right to S.LaPorta for 38 yards, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Lions score: Lions 7, Cardinals 7 (Q2 12:22) · 5:09 PM ET · (No Huddle) J.Gibbs up the middle for 1 yard, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
  • Cardinals score: Lions 0, Cardinals 7 (Q1 5:06) · 4:39 PM ET · J.Brissett pass short right to T.Quitoriano for 2 yards, TOUCHDOWN. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin.

Detroit Lions vs Arizona Cardinals odds (DraftKings)

Spread: Arizona Cardinals +5.5 (-112) · Detroit Lions -5.5 (-108)

Moneyline: Arizona Cardinals +205 · Detroit Lions -250

Total: Over 54.5 (-118) · Under 54.5 (-102)

Detroit Lions vs Arizona Cardinals picks

12 picks on Picksy, most on Cardinals ML (2 of 12); 2 won, 10 lost.

Who picked this game

More on Picksy

Lions vs Cardinals: questions & answers

Who won Lions vs Cardinals?

The Detroit Lions beat the Arizona Cardinals 45-21 on Sunday, October 11, 2026.

Who was favored in Lions vs Cardinals?

The Detroit Lions were favored at DraftKings: -5.5 on the spread and -250 on the moneyline.

What's the over/under for Lions vs Cardinals?

The total was 54.5 points at DraftKings (over -118, under -102). The game finished with 66, over the total.

What are the picks for Lions vs Cardinals?

12 picks on Picksy, most on Cardinals ML (2 of 12); 2 won, 10 lost.