Arizona Cardinals vs San Francisco 49ers Final Score, Odds & Picks
NFL · Sunday, September 27, 2026, 4:05 PM ET · Levi's Stadium, Santa Clara, CA · TV: Fox
Final: Arizona Cardinals 30, San Francisco 49ers 36.
Records: Arizona Cardinals 1-2, San Francisco 49ers 3-0.
Cardinals vs 49ers scoring plays
Final: Cardinals 30, 49ers 36 · 7:16 PM ET · San Francisco 49ers beat Arizona Cardinals 36-30.
Cardinals score: Cardinals 30, 49ers 36 (Q4 0:34) · 7:14 PM ET · C.Ryland 49 yard field goal is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
49ers score: Cardinals 27, 49ers 36 (Q4 1:31) · 7:07 PM ET · B.Purdy pass deep right to G.Kittle for 20 yards, TOUCHDOWN. E.Pineiro extra point is GOOD, Center-J.Weeks, Holder-C.Waitman.
Cardinals score: Cardinals 27, 49ers 29 (Q4 2:51) · 6:56 PM ET · (No Huddle) J.Brissett up the middle for 1 yard, TOUCHDOWN.Penalty on SF-O.Odighizuwa, Defensive Offside, declined. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
49ers score: Cardinals 20, 49ers 29 (Q4 8:42) · 6:45 PM ET · B.Purdy pass short middle to G.Kittle for 10 yards, TOUCHDOWN. E.Pineiro extra point is No Good, Hit Right Upright, Center-J.Weeks, Holder-C.Waitman.
Cardinals score: Cardinals 20, 49ers 23 (Q4 13:06) · 6:35 PM ET · J.Brissett pass short right to J.Love for 1 yard, TOUCHDOWN. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
Cardinals score: Cardinals 13, 49ers 23 (Q3 3:02) · 6:15 PM ET · J.Brissett pass short right to Mi.Wilson for 5 yards, TOUCHDOWN. C.Ryland extra point is GOOD, Center-C.Kreiter, Holder-B.Gillikin. SF-G.Halton was injured during the play.
49ers score: Cardinals 6, 49ers 23 (Q3 11:07) · 5:59 PM ET · C.McCaffrey up the middle for 1 yard, TOUCHDOWN. E.Pineiro extra point is No Good, Wide Left, Center-J.Weeks, Holder-C.Waitman.
49ers score: Cardinals 6, 49ers 17 (Q2 0:00) · 5:36 PM ET · E.Pineiro 57 yard field goal is GOOD, Center-J.Weeks, Holder-C.Waitman.PENALTY on ARZ-D.Robinson, Unnecessary Roughness, 15 yards, enforced between downs.
Cardinals score: Cardinals 6, 49ers 14 (Q2 0:23) · 5:30 PM ET · C.Ryland 41 yard field goal is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
Cardinals score: Cardinals 3, 49ers 14 (Q2 3:03) · 5:11 PM ET · C.Ryland 26 yard field goal is GOOD, Center-C.Kreiter, Holder-B.Gillikin.
49ers score: Cardinals 0, 49ers 14 (Q2 14:55) · 4:45 PM ET · (Shotgun) B.Purdy pass deep right to M.Evans for 23 yards, TOUCHDOWN. E.Pineiro extra point is GOOD, Center-J.Weeks, Holder-C.Waitman.
49ers score: Cardinals 0, 49ers 7 (Q1 8:26) · 4:20 PM ET · (Shotgun) B.Purdy pass short left to M.Evans to SF 20 for 2 yards. Lateral to D.Samuel for 80 yards, TOUCHDOWN. E.Pineiro extra point is GOOD, Center-J.Weeks, Holder-C.Waitman.
Arizona Cardinals vs San Francisco 49ers picks
2 picks on Picksy, most on Over 48.5 (1 of 2); 1 won, 1 lost.
Over 48.5 (-110) · by Ben Mintz Tracker (@MintzyTracker) · tracker · Won
49ers -6.5 (-150) · by MoneylineMav Tracker (@MoneylineMavTracker) · tracker · Lost