Detroit Lions vs Buffalo Bills Final Score, Odds & Picks
NFL · Thursday, September 17, 2026, 8:15 PM ET · Highmark Stadium, Orchard Park, NY · TV: Prime Video
Final: Detroit Lions 31, Buffalo Bills 41.
Records: Detroit Lions 1-1, Buffalo Bills 2-0.
Lions vs Bills scoring plays
Final: Lions 31, Bills 41 · 11:28 PM ET · Buffalo Bills beat Detroit Lions 41-31.
Lions score: Lions 31, Bills 41 (Q4 1:42) · 11:22 PM ET · (Shotgun) J.Goff pass deep middle to A.St. Brown for 27 yards, TOUCHDOWN [M.Danna]. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
Bills score: Lions 24, Bills 41 (Q4 2:50) · 11:11 PM ET · J.Cook right tackle for 1 yard, TOUCHDOWN. T.Bass extra point is GOOD, Center-R.Ferguson, Holder-T.Doman.
Lions score: Lions 24, Bills 34 (Q4 10:53) · 10:47 PM ET · J.Goff pass short left to S.LaPorta for 1 yard, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
Bills score: Lions 17, Bills 34 (Q3 1:07) · 10:30 PM ET · J.Allen scrambles right end for 2 yards, TOUCHDOWN. T.Bass extra point is GOOD, Center-R.Ferguson, Holder-T.Doman.
Lions score: Lions 17, Bills 27 (Q3 9:29) · 10:13 PM ET · (Shotgun) J.Goff pass short left to A.St. Brown for 2 yards, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
Lions score: Lions 10, Bills 27 (Q2 0:00) · 9:50 PM ET · J.Bates 31 yard field goal is GOOD, Center-H.Hatten, Holder-J.Fox.
Bills score: Lions 7, Bills 27 (Q2 2:52) · 9:23 PM ET · (Shotgun) J.Allen pass deep middle to D.Kincaid for 16 yards, TOUCHDOWN. T.Bass extra point is No Good, Wide Left, Center-R.Ferguson, Holder-T.Doman.
Lions score: Lions 7, Bills 21 (Q2 5:03) · 9:13 PM ET · (Shotgun) J.Goff pass short right to J.Gibbs for 11 yards, TOUCHDOWN. J.Bates extra point is GOOD, Center-H.Hatten, Holder-J.Fox.
Bills score: Lions 0, Bills 21 (Q2 11:48) · 9:02 PM ET · J.Allen pass short right to D.Knox for 1 yard, TOUCHDOWN. T.Bass extra point is GOOD, Center-R.Ferguson, Holder-T.Doman.
Bills score: Lions 0, Bills 14 (Q1 3:42) · 8:39 PM ET · (Shotgun) J.Allen pass deep middle to J.Palmer for 43 yards, TOUCHDOWN [S.Gill-Howard]. T.Bass extra point is GOOD, Center-R.Ferguson, Holder-T.Doman.
Bills score: Lions 0, Bills 7 (Q1 9:09) · 8:25 PM ET · (No Huddle) J.Allen left guard for 1 yard, TOUCHDOWN. T.Bass extra point is GOOD, Center-R.Ferguson, Holder-T.Doman.
Detroit Lions vs Buffalo Bills picks
7 picks on Picksy, most on Over 48.5 (1 of 7); 2 won, 4 lost.
Over 48.5 · by MoneylineMav Tracker (@MoneylineMavTracker) · tracker · parlay leg · Won
Bills +3.5 · by MoneylineMav Tracker (@MoneylineMavTracker) · tracker · parlay leg · Won