About this game

Denver Broncos vs Arizona Cardinals Prediction, Odds & Picks

NFL · Sunday, October 25, 2026, 4:05 PM ET · State Farm Stadium, Glendale, AZ · TV: CBS

Records: Denver Broncos 4-2, Arizona Cardinals 2-4.

Denver Broncos vs Arizona Cardinals odds (DraftKings)

Spread: Arizona Cardinals +4.5 (-105) · Denver Broncos -4.5 (-115)

Moneyline: Arizona Cardinals +195 · Denver Broncos -238

Total: Over 42.5 (-120) · Under 42.5 (+100)

Denver Broncos vs Arizona Cardinals picks

4 picks on Picksy, most on Broncos ML (2 of 4).

Who picked this game

More on Picksy

Broncos vs Cardinals: questions & answers

What time does Broncos vs Cardinals start?

Denver Broncos at Arizona Cardinals starts Sunday, October 25, 2026 at 4:05 PM ET, at State Farm Stadium in Glendale, AZ.

Who is favored in Broncos vs Cardinals?

The Denver Broncos are favored at DraftKings: -4.5 on the spread and -238 on the moneyline.

What's the over/under for Broncos vs Cardinals?

The total is 42.5 points at DraftKings (over -120, under +100).

What channel is Broncos vs Cardinals on?

Denver Broncos at Arizona Cardinals is on CBS.

What are the picks for Broncos vs Cardinals?

4 picks on Picksy, most on Broncos ML (2 of 4).